Neural DSP Archetype: John Mayer X settings
Layla settings for Neural DSP Archetype: John Mayer X
Derek and the Dominos · adapted 4 times on ToneAdapt
To get the Derek and the Dominos "Layla" riff tone on a Neural DSP Archetype: John Mayer X, use the Drive amp model on the crunch channel, then set Drive 7, Master 7, Bass 5, Mid 6, Treble 7, Presence 6. Use the bridge pickup with your guitar's tone on 8-10 and volume on 10.
Riff settings
Adapted for a PRS SE Silver Sky · updated 2026-10-18
- Amp model
- Drive
- Channel
- Crunch
- Cab
- 4x12 cabinet
- Pickup
- Bridge pickup
- Guitar knobs
- Tone 8-10 · Volume 10
Amp block
- Drive
- 7
- Master
- 7
- Bass
- 5
- Mid
- 6
- Treble
- 7
- Presence
- 6
Effects chain
- 1reverbPlate ReverbMix 2 · Decay 2
Playing tips
- Focus on a compressed but aggressive picking attack to capture the original tone's energy.
- Use fingerstyle for a more nuanced dynamic range, especially on the descending riff.
- Experiment with palm muting on certain notes to add punch and clarity.
The original rig
What Derek and the Dominos used on the recording, for reference. ToneAdapt translates this to the controls your Neural DSP Archetype: John Mayer X actually has.
- Guitar
- 1960 Fender Stratocaster 'Brownie'
- Amp
- Fender Champ (1957, tweed), possibly Vibro Champ or Princeton in some sessions
- Gain
- 6
- Bass
- 6
- Mid
- 6.5
- Treble
- 7.5
- Presence
- 5.5
- Reverb
- 2.5
Different guitar or pedals? Get Layla adapted to your exact rig
These settings were generated for the gear named above. ToneAdapt adapts Derek and the Dominos's tone to your own guitar, pickups, amp and pedals in seconds.
Frequently asked questions
What amp model should I use on the Neural DSP Archetype: John Mayer X for Layla?
Use the Drive (crunch channel) with Drive 7, Master 7, Bass 5, Mid 6, Treble 7, Presence 6, followed by Plate Reverb.
Which pickup should I use for Layla?
Bridge pickup, with the guitar's tone at 8-10 and volume at 10.
What gear did Derek and the Dominos use on Layla?
Guitar: 1960 Fender Stratocaster 'Brownie'. Amp: Fender Champ (1957, tweed), possibly Vibro Champ or Princeton in some sessions.
Will these settings work with my guitar?
These settings were adapted for a PRS SE Silver Sky. Different pickups change how much gain and treble you need. ToneAdapt adapts the tone to your exact guitar, pickups, amp and pedals.
Layla on other amps
Popular songs on the Neural DSP Archetype: John Mayer X
- Pride and Joy · Stevie Ray Vaughan
- Sultans of Swing · Dire Straits
- Hotel California · Eagles
- Stairway to Heaven · Led Zeppelin
- Black Magic Woman · Santana
- Enter Sandman · Metallica
- Gravity · John Mayer
- Tadow · Masego
- Creep · Radiohead
- Belief · John Mayer
Settings are generated by ToneAdapt's tone adaptation for the gear named on this page and are a starting point — every amp, guitar and room is a little different.