Neural DSP Quad Cortex settings
Layla settings for Neural DSP Quad Cortex
Derek and the Dominos · adapted 16 times on ToneAdapt
To get the Derek and the Dominos "Layla" riff tone on a Neural DSP Quad Cortex, use the Brit Plexi 100 Normal (Marshall Super Lead 100) amp model on the crunch channel, then set Drive 7, Master 7, Bass 5, Mid 6, Treble 7, Presence 6. Use the bridge pickup with your guitar's tone on 8-10 and volume on 10.
Riff settings
Adapted for a Fender Stratocaster · updated 2026-10-25
- Amp model
- Brit Plexi 100 Normal (Marshall Super Lead 100)
- Channel
- Crunch
- Cab
- 4x12 cabinet
- Pickup
- Bridge pickup
- Guitar knobs
- Tone 8-10 · Volume 10
Amp block
- Drive
- 7
- Master
- 7
- Bass
- 5
- Mid
- 6
- Treble
- 7
- Presence
- 6
Effects chain
- 1overdriveGreen 808 (Ibanez TS808)Gain 4 · Tone 6 · Level 7
- 2compressionChief CS3 (BOSS CS-3 Compression Sustainer)Level 6 · Sustain 5
- 3reverbPlateMix 4 · Decay 3
Built-in effects
- Reverb off
Playing tips
- Focus on a compressed but aggressive picking attack to emulate the original tone.
- Use fingerstyle for a more nuanced approach, as Clapton often did.
- Ensure to maintain a steady rhythm while playing the descending riff.
The original rig
What Derek and the Dominos used on the recording, for reference. ToneAdapt translates this to the controls your Neural DSP Quad Cortex actually has.
- Guitar
- 1960 Fender Stratocaster 'Brownie'
- Amp
- Fender Champ (1957, tweed), possibly Vibro Champ or Princeton in some sessions
- Gain
- 6
- Bass
- 6
- Mid
- 6.5
- Treble
- 7.5
- Presence
- 5.5
- Reverb
- 2.5
Different guitar or pedals? Get Layla adapted to your exact rig
These settings were generated for the gear named above. ToneAdapt adapts Derek and the Dominos's tone to your own guitar, pickups, amp and pedals in seconds.
Frequently asked questions
What amp model should I use on the Neural DSP Quad Cortex for Layla?
Use the Brit Plexi 100 Normal (Marshall Super Lead 100) (crunch channel) with Drive 7, Master 7, Bass 5, Mid 6, Treble 7, Presence 6, followed by Green 808 (Ibanez TS808), Chief CS3 (BOSS CS-3 Compression Sustainer), Plate.
Which pickup should I use for Layla?
Bridge pickup, with the guitar's tone at 8-10 and volume at 10.
What gear did Derek and the Dominos use on Layla?
Guitar: 1960 Fender Stratocaster 'Brownie'. Amp: Fender Champ (1957, tweed), possibly Vibro Champ or Princeton in some sessions.
Will these settings work with my guitar?
These settings were adapted for a Fender Stratocaster. Different pickups change how much gain and treble you need. ToneAdapt adapts the tone to your exact guitar, pickups, amp and pedals.
Layla on other amps
Popular songs on the Neural DSP Quad Cortex
- Sweet Child O' Mine · Guns N' Roses
- Master of Puppets · Metallica
- Walk · Pantera
- Enter Sandman · Metallica
- Holy Wars · Megadeth
- Raining Blood · Slayer
- Hotel California · Eagles
- Crazy Train · Ozzy Osbourne
- Welcome to the Jungle · Guns N' Roses
- Highway to Hell · AC/DC
- Pride and Joy · Stevie Ray Vaughan
- Whole Lotta Love · Led Zeppelin
Settings are generated by ToneAdapt's tone adaptation for the gear named on this page and are a starting point — every amp, guitar and room is a little different.